carboxypeptidase A4 (CPA4, UNQ694/PRO1339)

Function

• metalloprotease
• may be involved in histone hyperacetylation pathway
• interacts with LXN

Cofactor: binds 1 Zn+2 per subunit

Structure

belongs to the peptidase M14 family

Compartment

secreted (putative)

Expression

• fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver & lung
• except for fetal brain that shows no imprinting, expression found preferentially from maternal allele
• up-regulated by inhibitors of histone dacetylation

More general terms

• carboxypeptidase-A
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/607635
• UniProt: http://www.uniprot.org/uniprot/Q9UI42.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51200