ribonuclease 1 (RNase 1, ribonuclease-A, RNase-A, RNase UPI-1, pancreatic ribonuclease)

Function

• endonuclease catalyzes cleavage of RNA on 3' side of pyrimidine nucleotides
• acts on single stranded RNA & double stranded RNA
• endonucleolytic cleavage to nucleoside 3'-phosphates & 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates

Structure

• monomer
• belongs to the pancreatic ribonuclease family
• glycoprotein, N-linked glycans are of complex type

Compartment

secreted

Expression

• pancreas & other tissues & body fluids (suggesting it may have other physiological functions besides its role in digestion)

More general terms

• endoribonuclease
• secreted protein
• pancreatic ribonuclease family
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P07998.html
• OMIM: https://mirror.omim.org/entry/180440
• OMIM: https://mirror.omim.org/entry/180540