protein INCA1 (inhibitor of CDK interacting with cyclin A1) (INCA1)

Function

• interacts with CCNA1
• identified in a complex with CCNA1 & CDK2
• phosphorylated when part of a complex with CCNA1 & CDK2 strongly phosphorylated by CDK2 on its C-terminal region spanning amino acid 149-221
• less intensively phosphorylated by CDK2 on its first 75 amino acid residues

Structure

belongs to the INCA family

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• detected in testis, & at lower levels in ovary

Pathology

• detected at very low levels in testis tumors

More general terms

• nuclear protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3883
• UniProt: http://www.uniprot.org/uniprot/Q0VD86.html