Death-inducing protein (DIP, GRAMD4, KIAA0767)

Function

• plays a role as a mediator of E2F1-induced apoptosis in the absence of TP53/p53

Structure

contains 1 GRAM domain

Compartment

• mitochondrial membrane
• colocalizes with COX4I1

Alternative splicing

named isoforms=2

Expression

• expressed in lung & in primary lung squamous cell carcinoma
• up-regulated in the mitochondria by E2F1 after addition of 4-hydroxytamoxifen (at protein level)

More general terms

• mitochondrial membrane protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2315
• UniProt: http://www.uniprot.org/uniprot/Q6IC98.html