influenza antigen test
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Clinical significance
- test will distinguish influenza A & B
- negative test does NOT exclude influenza infection
- tests might not detec virus at low concentrations[3]
- specificity = 98% but sensitivity = 54% in adults & 67% in children[2]
- variable results among 11 different diagnostic tests[3]
- positive test does NOT exclude coinfection with another pathogen
- viral culture suggested for suspected influenza infection when influenza antigen test is negative
Methods
- turn around time 30 minutes
Specimen
Differential diagnosis
Notes
- office-based tests performed poorly during 2009 H1N1 pandemic
- FDA proposes regulation to meet quality control specifications[4]
More general terms
Additional terms
References
- ↑ Veterans Administration
- ↑ 2.0 2.1 Chartrand C et al Accuracy of Rapid Influenza Diagnostic Tests: A Meta-analysis Annals of Internal Medicine February 21, 2012, 156(4) <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22371850 <Internet> http://www.annals.org/content/early/2012/02/27/0003-4819-156-7-201204030-00403.abstract
- ↑ 3.0 3.1 3.2 Centers for Disease Control and Prevention Evaluation of 11 Commercially Available Rapid Influenza Diagnostic Tests -- United States, 2011-2012 MMWR, November 2, 2012 / 61(43);873-876 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6143a3.htm
- ↑ 4.0 4.1 Executive Summary Proposed Reclassification of the Rapid Influenza Detection Tests CDRH Microbiology Devices Advisory Committee Meeting June 13, 2013, Gaithersburg, Maryland http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/MedicalDevices/MedicalDevicesAdvisoryCommittee/MicrobiologyDevicesPanel/UCM356185.pdf