Elongator complex protein 3; hELP3 (ELP3)

Function

• catalytic histone acetyltransferase subunit of the RNA polymerase 2 elongator complex
• may also have a methyltransferase activity
• component of the RNA polymerase 2 elongator complex
• interacts with IKBKAP/ELP1

acetyl-CoA + histone <--> CoA + acetylhistone

Structure

• belongs to the ELP3 family
• contains 1 N-acetyltransferase domain

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=3

More general terms

• enzyme catalytic subunit
• phosphoprotein
• metalloprotein

Component of

• RNA polymerase 2 elongator complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H9T3.html