presqualene diphosphate phosphatase (phosphatidic acid phosphatase type 2 domain-containing protein 2, PPAPDC2)

Function

• phosphatase
• dephosphorylates presqualene diphosphate into presqualene monophosphate
• indirectly involved in innate immunity (putative)
• pyrophosphatase activity with a substrate preference presqualene diphosphate > fructose diphastate > phosphatidic acid

Kinetic parameters:

• Optimum pH is 7-8

Structure

• belongs to the PA-phosphatase related phosphoesterase family

Compartment

membrane

Expression

• widely expressed
• expressed in most organs, in particular gastrointestinal organs, spleen, placenta, kidney, thymus & brain

More general terms

• transmembrane 4 protein
• phosphodiesterase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IY26.html