oligoribonuclease, mitochondrial (small fragment nuclease, RNA exonuclease 2 homolog, REXO2, SFN, SMFN, CGI-114)

Function

• 3'-to-5' exoribonuclease specific for small oligoribonucleotides
• active on small (primarily <= 5 nucleotides in length, single-stranded RNA & DNA oligomers
• role in cellular nucleotide recycling (putative)

Cofactor: Mn+2

Structure

• homotetramer
• belongs to the oligoribonuclease family

Compartment

isoform 1: mitochondrion isoform 2: nucleus

Alternative splicing

named isoforms=2

More general terms

• exoribonuclease
• mitochondrial protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/607149
• UniProt: http://www.uniprot.org/uniprot/Q9Y3B8.html