S-methyl-5-thioadenosine phosphorylase (5'-methylthioadenosine phosphorylase, MTA phosphorylase, MTAPase, MTAP, MSAP)

Function

Function:

• role in polyamine metabolism
• role in salvage of both adenine & methionine
• inhibited by 5'-methylthiotubercin & 5'-chloroformycin

S-methyl-5-thioadenosine + phosphate
          <-->
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

Structure

homotrimer

Compartment

cytoplasm

Expression

ubiquitously expressed

More general terms

• glycosyltransferase
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/156540
• UniProt: http://www.uniprot.org/uniprot/Q13126.html