pre-mRNA-processing factor 40 homolog B (Huntingtin-interacting protein HYPC, Huntingtin yeast partner C, PRPF40B, HYPC)

Function

• may be involved in pre-mRNA splicing
• interacts with the N-terminus of HD

Structure

belongs to the PRPF40 family contains 2 FF domains contains 2 WW domains

Compartment

nuclear speckle

Alternative splicing

named isoforms=4

Expression

• expressed in the striatum & cortex of the brain (at protein level)
• highly expressed in testis, fetal kidney & fetal brain
• moderately expressed in pancreas, skeletal muscle, placenta, brain & heart
• weakly expressed in colon, ileum, ovary, prostate, spleen, kidney & fetal lung

More general terms

• nuclear protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6NWY9.html