shootin-1 (KIAA1598)

Function

• role in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity
• accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons
• interacts with RUFY3 (putative)

Structure

belongs to the shootin family

Compartment

cell projection, axon (putative)

Alternative splicing

named isoforms=4

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/A0MZ66.html