Shugoshin-like 2 (Tripin) (SGOL2)

Function

• role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex from centromeres after prophase (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

belongs to the shugoshin family

Compartment

nucleus (putative), centromere

• localizes to the centromere (putative)

Alternative splicing

named isoforms=3

More general terms

• phosphoprotein
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q562F6.html