microtubule-associated protein 9 (Aster-associated protein, MAP9, ASAP)
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Function
- role in organization of the bipolar mitotic spindle
- required for bipolar spindle assembly, mitosis progression & cytokinesis
- may act by stabilizing interphase microtubules
- binds to purified microtubules via its C-terminus
- phosphorylated upon DNA damage, probably by ATM or ATR
Compartment
- cytoplasm, cytoskeleton, spindle
- localizes to microtubules in interphase
- associates with mitotic spindle during mitosis
- localizes to the central body during cytokinesis
Alternative splicing
named isoforms=2
Expression
constitutively expressed during the cell cycle