SIRT6 knockout mouse
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Introduction
Features:
- deficient DNA repair
- chromosome breakages
- born small
- loss subcutaneous fat
- lordosis & kyphosis of the spine
- lymphopenia
- involution of the spleen & thymus
- severe hypoglycemia
- death at 4 weeks
More general terms
Additional terms
References
- ↑ Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 2006 Jan 27;124(2):315-29. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16439206