MARVEL domain-containing protein 2 (tricellulin, MARVELD2, TRIC)

Function

• role in the formation of the epithelial barrier
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

contains 1 MARVEL domain

Compartment

• membrane
• found at tricellular contacts

Alternative splicing

named isoforms=2

Pathology

• defects in MARVELD2 are the cause of autosomal recessive congenital sensorineural deafness type 49

More general terms

• transmembrane 6 protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8N4S9.html