nuclear prelamin A recognition factor

Function

• interacts with LMNA & binds to its farnesylated C-terminal domain
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

belongs to the NARF family

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• ubiquitous
• predominantly expressed in skeletal muscle, heart, brain

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/605349
• UniProt: http://www.uniprot.org/uniprot/Q9UHQ1.html