WW domain-binding protein 11 (WBP-11, SH3 domain-binding protein SNP70, Npw38-binding protein, NpwBP, WBP11)

Function

• role in regulation of pre-mRNA processing
• interacts via PGR motif with PQBP1 in nucleus

Compartment

• nucleus, cytoplasm
• predominantly located in nucleus with granular heterogeneous distribution
• excluded from nucleoli in interphase cells
• distributed throughout cytoplasm in dividing cells
• co-localized with SC35 & U2B in nucleus
• in cytoplasm, associates with intermediate filament protein vimentin

Expression

• ubiquitous
• expressed in heart, pancreas, kidney, skeletal muscle, placenta & brain (at protein level) > liver & lung

More general terms

• WW domain-binding protein
• phosphoprotein
• SH3 domain-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y2W2.html