protein NDRG2 (protein Syld709613, NDRG2, KIAA1248, SYLD)

Function

• role in dendritic cell & neuron differentiation
• anti-tumor activity

Structure

• belongs to the NDRG family

Compartment

• cytoplasm, perinuclear region
• perinuclear in neurons

Alternative splicing

named isoforms=5

Expression

• expressed in brain, heart, skeletal muscle, salivary gland > kidney, liver
• expressed in dendritic cells, but not in other blood cells
  • specifically expressed during dendritic cell differentiation (in vitro)
• Isoforms 1 & 2 are present in brain neurons
  • expression is low in fetal brain & increases during brain post-natal development

Pathology

• generally not expressed in tumor cell lines
• not expressed or strongly down-regulated in various cancers, including astrocytoma, meningioma, liver cancer, pancreatic cancer
• found in pathological brain lesions of Alzheimer disease
• isoforms 1 & 2 are up-regulated in Alzheimer disease (at protein level)

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/605272
• UniProt: http://www.uniprot.org/uniprot/Q9UN36.html