hematopoietic SH2 domain-containing protein (hematopoietic SH2 protein, adaptor in lymphocytes of unknown function X, HSH2D, ALX)

Function

• modulates apoptotis via mitochondrial stability
• adapter protein involved in tyrosine kinase & CD28 signaling
• affect CD28-mediated activation of RE/AP element of IL2 promoter
• interacts with FES & TNK2
• phosphorylated by FES, ACK1

Structure

• contains 1 SH2 domain

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=2

Expression

• predominantly expressed in spleen & hematopoietic cells, i.e. peripheral blood leukocytes > prostate, thymus, heart, small intestine, placenta

More general terms

• SH2 domain-containing protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/608349
• UniProt: http://www.uniprot.org/uniprot/Q96JZ2.html