hook homolog 3 (hHK3, HOOK3)

Function

• cytoskeletal linker protein
• role in tethering Golgi complex to cytoskeleton
• role in defining architecture & localization of Golgi
• interacts with microtubules

Structure

• homodimer, larger coiled coil domain
• belongs to the hook family
• associates with cis-face of the Golgi

Pathology

• target for the spiC protein from Salmonella typhimurium, which inactivates it, resulting in alteration in cellular trafficking

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/607825
• UniProt: http://www.uniprot.org/uniprot/Q86VS8.html