F-box only protein-38 (modulator of KLF7 activity homolog, MoKA, FBXO38)

Function

• promotes ubiquitination & degradation of undetermined phosphoproteins
• coactivates KLF7, but does not promote KLF7 ubiquitination
• component of SCF complex

Structure

• N-terminal region aa 1-349 seems to be involved in cytoplasmic localization (putative)
• C-terminal region aa 473-1194 seems to be involved in nuclear localization (putative).
• contains 1 F-box domain

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=3

More general terms

• F-box only protein
• phosphoprotein

Component of

• SCF-type E3 ligase complex

Database

• OMIM: https://mirror.omim.org/entry/608533
• UniProt: http://www.uniprot.org/uniprot/Q6PIJ6.html