transcription termination factor 1 (TTF-1, RNA polymerase I termination factor, TTF1)

Function

• multifunctional nucleolar protein
• terminates ribosomal gene transcription
• mediates replication fork arrest
• regulates RNA polymerase 1 transcription on chromatin
• role in rDNA regulation, role in both activation & silencing of rDNA transcription
• interaction with TIP5 recovers DNA-binding activity
• N-terminal region inhibits DNA-binding via its interaction with the C-terminal region

Structure

• oligomer, enables TTF1 to interact simultaneously with 2 separate DNA fragments
• contains 2 Myb DNA-binding domains

Compartment

nucleus, nucleolus

More general terms

• DNA-binding protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/600777
• UniProt: http://www.uniprot.org/uniprot/Q15361.html