abnormal spindle-like microcephaly-associated protein (abnormal spindle protein homolog, Asp homolog, ASPM MCPH5)

Function

• role in mitotic spindle regulation (putative)
• coordination of mitotic processes
• role in regulating neurogenesis

Structure

• contains 2 CH doamins (calponin-homology domains)
• contains 39 IQ domains

Compartment

• cytoplasm, nucleus
• nuclear-cytoplasmic distribution may be regulated by calmodulin

Alternative splicing

named isoforms=2

Pathology

• defects in ASPM are associated with primary microcephaly 5

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/251200
• OMIM: https://mirror.omim.org/entry/605481
• OMIM: https://mirror.omim.org/entry/608716
• UniProt: http://www.uniprot.org/uniprot/Q8IZT6.html