breast cancer anti-estrogen resistance protein 3; SH2 domain-containing protein 3B; novel SH2-containing protein 2 (BCAR3, NSP2, SH2D3B, UNQ271/PRO308)

Function

• adapter protein
• couples activated growth factor receptors to a signals that regulate proliferation in breast cancer cells
• regulated by cellular adhesion to extracellular matrix
• interacts with BCAR1, NEDD9, PTK2, PTPN1
• phosphorylated on Ser & Tyr

Alternative splicing

named isoforms=2

Expression

ubiquitously expressed

Pathology

• found in several cancer cell lines, but not in nonmalignant breast tissue
• when overexpressed, confers anti-estrogen resistance in breast cancer cell lines

More general terms

• SH2 domain-containing protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/604704
• UniProt: http://www.uniprot.org/uniprot/O75815.html