protein tyrosine phosphatase non-receptor type 1; protein tyrosine phosphatase 1B (PTPN1, PTP1B)
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Function
- may play an important role in CKII- & p60c-src-induced signal transduction cascades (putative)
- oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding & activity
- active site can be restored by reduction
Structure
- belongs to the protein-tyrosine phosphatase family non-receptor class 1 subfamily
- contains 1 tyrosine-protein phosphatase domain
Compartment
- endoplasmic reticulum membrane, cytoplasmic side
Polymorphism
- genetic variation in PTPN1 may influence abdominal body fat distribution
More general terms
References
- ↑ Rohan PJ, Davis P, Moskaluk CA, Kearns M, Krutzsch H, Siebenlist U, Kelly K. PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science. 1993 Mar 19;259(5102):1763-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7681221
- ↑ Barford D, Flint AJ, Tonks NK. Crystal structure of human protein tyrosine phosphatase 1B. Science. 1994 Mar 11;263(5152):1397-404. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8128219
- ↑ UniProt http://www.uniprot.org/uniprot/P18031.html