zinc finger FYVE domain-containing protein 16 (endofin, endosome-associated FYVE domain protein, ZFYVE16, KIAA0305)

Function

• regulating membrane trafficking in the endosomal pathway
• overexpression induces endosome aggregation
• targets TOM1 to endosomes, interacts with C-terminus of TOM1
  • does not interact with TOM1L1 or TOM1L2
• FYVE-type zinc finger localizes ZFYVE16 to early endosomes & mediates association with PI3P

Compartment

• localized to early endosomes, membrane-associated, probably via association with phosphatidylinositol 3-phosphate (PI3P)

Alternative splicing

named isoforms=3

Expression

• widely expressed
• expressed in kidney, placenta, lung > heart, brain, skeletal muscle, spleen, liver > colon, thymus, peripheral blood lymphocytes

More general terms

• phosphoprotein
• zinc finger FYVE domain-containing protein (ZFYVE)

Database

• OMIM: https://mirror.omim.org/entry/608880
• UniProt: http://www.uniprot.org/uniprot/Q7Z3T8.html