Hsc70-interacting protein (Hip, suppression of tumorigenicity protein 13, putative tumor suppressor ST13, protein FAM10A1, progesterone receptor-associated p48 protein, NY-REN-33 antigen, ST13, FAM10A1, HIP, SNC6)

Function

• oligomer binds ATPase domains of at least two HSC70
• dependent on activation of the HSC70 ATPase by HSP40
• stabilizes ADP state of HSC70
• interacts with HSC7, DNAJ homologs, HSP90
• chaperone

Structure

homotetramer

Compartment

cytoplasm

More general terms

• chaperonin; chaperone
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/606796
• UniProt: http://www.uniprot.org/uniprot/P50502.html