ATPase WRNIP1; Werner helicase-interacting protein 1 (WRNIP1, WHIP)

Function

• modulates initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis
• intrinsic ATPase activity
• sensor of DNA damage or of arrested replication forks
• regulates the extent of DNA synthesis
• interacts with POLD1, POLD2, POLD4
• interacts with the N-terminal domain of WRN
• interacts (via UBZ-type Zn+2 finger) with polyubiquitin

Structure

• homooligomer, most likely an octamer
• belongs to the AAA ATPase family
• contains 1 UBZ-type Zn+2 finger Coompartment:
• nucleus (putative)
• colocalizes with WRN in granular structures in the nucleus

Alternative splicing

named isoforms=4

Expression

ubiquitously expressed

More general terms

• phosphoprotein
• adenosine triphosphatase (ATPase)
• oligomerizing protein

Additional terms

• Werner syndrome ATP-dependent helicase (WRN, RECQ3, RECQL2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56897
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56897
• OMIM: https://mirror.omim.org/entry/608196
• UniProt: http://www.uniprot.org/uniprot/Q96S55.html