pallidin; pallid protein homolog; syntaxin 13-interacting protein (PLDN, PA, BLOC1S6)

Function

• role in the development of lysosome-related organelles, such as melanosomes & platelet-dense granules
• may play a role in intracellular vesicle trafficking, particularly in the vesicle-docking & fusion process
• phosphorylated
• the major soluble form is part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)
• interacts with CNO/cappuccino & DTNBP1 (putative)
• interacts with MUTED, syntaxin 13 & F-actin
• strongly interacts with itself

Compartment

• cytoplasm, endomembrane system, peripheral membrane

Alternative splicing

named isoforms=3

Expression

widely expressed

Pathology

• defects in PLDN are the cause of Hermansky-Pudlak syndrome type 9

More general terms

• protein subunit
• phosphoprotein

Additional terms

• Palladin (sarcoma antigen NY-SAR-77, SIH002, PALLD, KIAA0992, CGI-151)

Component of

• biogenesis of lysosome-related organelles complex-1 (BLOC-1 complex)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26258
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26258
• OMIM: https://mirror.omim.org/entry/604310
• OMIM: https://mirror.omim.org/entry/614171
• UniProt: http://www.uniprot.org/uniprot/Q9UL45.html