fasciculation & elongation protein zeta-1; zygin I; zygin-1 (FEZ1)

Function

• may be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology & axon guidance machinery
• able to restore partial locomotion & axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments
• phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B & polyubiquitination
• polyubiquitination (UBE4B-dependent) does not lead to proteasomal degradation but may play role in neurogenic activity
• polyubiquitin linkage seems to be mainly through Lys-26
• interacts with the NH2-terminal variable region (V1) of PKC zeta & weakly with that of PKC epsilon (putative)
• interacts with UBE4B
• interacts with SAP30L

Structure

• belongs to the zygin family

Compartment

• cytoplasm (putative)
• cell membrane
• translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (putative)

Alternative splicing

named isoforms=2; long, short

Expression

• expressed mainly in brain

More general terms

• fasciculation and elongation protein zeta or zygin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9638
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9638
• OMIM: https://mirror.omim.org/entry/604825
• UniProt: http://www.uniprot.org/uniprot/Q99689.html