necrobiotic xanthogranuloma
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Etiology
- paraproteinemia 99% (generally IgG kappa)
- multiple myeloma may develop[3]
Pathology
- cutaneous & subcutaneous xanthogranulomas
- focal necrosis
- giant cells
- associated with paraproteinemia (99%)
- generally monoclonal gammopathy (IgG kappa)
* histopathology images[4][5][6]
Clinical manifestations
- multiple, large, sometimes ulcerated, red to yellow (purple to orange) granulomatous nodules & indurated plaques
- atrophy & telangiectasias
- may occur on trunk or periorbital areas, especially upper eyelids[3]
Laboratory
- serum protein electrophoresis shows
- IgG kappa paraproteinemia, or
- multiple myeloma
- urine protein electrophoresis for Bence Jones protein
Management
- symptomatic, treatment ineffective[6]
More general terms
References
- ↑ Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999
- ↑ Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 177-78
- ↑ 3.0 3.1 3.2 Medical Knowledge Self Assessment Program (MKSAP) 17, 18. American College of Physicians, Philadelphia 2015, 2018.
- ↑ 4.0 4.1 4.2 Wood AJ, Wagner MV, Abbott JJ, Gibson LE Necrobiotic XanthogranulomaA Review of 17 Cases With Emphasis on Clinical and Pathologic Correlation. Arch Dermatol. 2009;145(3):279-284. <PubMed> PMID: https://pubmed.ncbi.nlm.nih.gov/19289757 <Internet> http://archderm.jamanetwork.com/article.aspx?articleid=711962
- ↑ 5.0 5.1 DermNet NZ. (histopathology images) Necrobiotic xanthogranuloma pathology
- ↑ 6.0 6.1 6.2 6.3 Shen YH, Chen WY, Chiang YY. Widespread Yellowish to Brownish Plaques and Nodules. Mayo Clin Proc. 2026 Mar 21:S0025-6196(26)17357-1 PMID: https://pubmed.ncbi.nlm.nih.gov/41863518 https://www.mayoclinicproceedings.org/article/S0025-6196(26)17357-1/fulltext