forkhead box protein J2; Fork head homologous X (FOXJ2, FHX)

Function

• transcriptional activator
• able to bind to two different type of DNA binding sites
• isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

contains 1 fork-head DNA-binding domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

widely expressed

More general terms

• forkhead family transcription factor
• zinc finger protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9P0K8.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55810