chromodomain-helicase-DNA-binding protein 9;ATP-dependent helicase CHD9; CHD-9; chromatin-related mesenchymal modulator; CReMM, chromatin remodeling factor CHROM1; peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein; PPAR-alpha-interacting complex protein 320 kD; Kismet homolog 2 (CHD9, KIAA0308, KISH2, PRIC320)

Function

• transcriptional coactivator for PPARA
• ATP-dependent chromatin remodeling (putative)
• DNA-dependent ATPase activity
• binds to A/T-rich DNA
• differentiation of progenitors during osteogenesis
• interacts with PPARA, ESR, NR1I3
• phosphorylated on Ser & Tyr

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=3

Expression

• widely expressed at low levels
• in bone marrow, expression is restricted to osteoprogenitor cells adjacent to mature osteoblasts

More general terms

• chromodomain-helicase-DNA-binding protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q3L8U1.html