G protein-coupled receptor kinase-5 (GRK5, GPRK5)

Function

• specifically phosphorylates activated forms of G protein-coupled receptors

ATP + [G-protein-coupled receptor]
             <-->
ADP + [G-protein-coupled receptor] phosphate

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 1 protein kinase domain
• contains 1 RGS domain

Expression

• expressed in heart, placenta, lung > skeletal muscle > brain, liver, pancreas > kidney

More general terms

• G protein-coupled receptor kinase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P34947.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2869
• OMIM: https://mirror.omim.org/entry/600870
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2869