ATP citrate lyase (citrate cleavage enzyme, ACLY)

Function

• ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues
• role in de novo lipid synthesis.
• in nervous tissue it may be involved in the biosynthesis of acetylcholine

ADP + phosphate + acetyl-CoA + oxaloacetate
       <-->
ATP + citrate + CoA

Structure

• homotetramer
• N-terminal: succinate/malate CoA ligase beta subunit family
• C-terminal: succinate/malate CoA ligase alpha subunit family

Compartment

cytoplasm

Notes

• contrast to mitochondrial citrate synthase of citric acid cycle

More general terms

• ketoacid-lyase
• phosphoprotein
• oligomerizing protein

More specific terms

• citrate lyase beta subunit-like protein, mitochondrial; citrate lyase beta-like; beta-methylmalate synthase (CLYBL, CLB)

Additional terms

• citrate synthase, mitochondrial; NADH cytochrome C reductase (CS)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:47;
• OMIM: https://mirror.omim.org/entry/108728
• UniProt: http://www.uniprot.org/uniprot/P53396.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=47