citrate synthase, mitochondrial; NADH cytochrome C reductase (CS)

Function

• carbohydrate metabolism; tricarboxylic acid cycle

acetyl-CoA + H2O + oxaloacetate <--> citrate + CoA

Structure

• homodimer (putative)
• belongs to the citrate synthase family

Compartment

mitochondria matrix

Expression

• citrate synthase is found in nearly all cells capable of oxidative metabolism

Laboratory

• citrate synthase in amniotic fluid
• citrate synthase in amniotic fluid cells
• citrate synthase in fibroblasts
• citrate synthase in leukocytes
• citrate synthase in tissue

More general terms

• ketoacid-lyase
• citric acid cycle enzyme
• oligomerizing protein

Additional terms

• ATP citrate lyase (citrate cleavage enzyme, ACLY)
• citric acid cycle, Krebs cycle or tricarboxylic acid [TCA] cycle

Database

• OMIM: https://mirror.omim.org/entry/118950
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1431
• UniProt: http://www.uniprot.org/uniprot/O75390.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1431