seryl-tRNA synthetase (serine-tRNA ligase, SerRS, SARS)

Function

• catalyzes the attachment of serine to tRNA(Ser)
• also probably able to aminoacylate tRNA(sec) with serine, to form the misacylated tRNA L-seryl-tRNA(sec), which will be further converted into selenocysteinyl-tRNA(sec)
• aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(sec)
• biosynthesis; L-seryl-tRNA(sec) from L-serine & tRNA(sec): step 1/1
• phosphorylated upon DNA damage, probably by ATM or ATR

ATP + L-serine + tRNA(Ser)
           <-->
AMP + diphosphate + L-seryl-tRNA(Ser)

ATP + L-serine + tRNA(sec)
           <-->
AMP + diphosphate + L-seryl-tRNA(sec)

Structure

• homodimer
• tRNA molecule binds across the dimer
• consists of two distinct domains, a catalytic core & a N-terminal extension that is involved in tRNA binding
• belongs to aminoacyl-tRNA synthetase-2 family, type-1 seryl-tRNA synthetase subfamily

Compartment

cytoplasm

More general terms

• amino acyl tRNA synthetase-2
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6301
• OMIM: https://mirror.omim.org/entry/607529
• UniProt: http://www.uniprot.org/uniprot/P49591.html