Na+/K+ ATPase-alpha 2; Na+ pump subunit alpha-2; Na+/K+ ATPase alpha-2 subunit (ATP1A2, KIAA0778)

Function

• catalytic component of the active Na+/K+ ATPase, which catalyzes hydrolysis of ATP coupled with exchange of Na+ & K+ ions across the plasma membrane
• this action creates the electrochemical gradient of Na+ & K+, providing the energy for active transport of various nutrients

Structure

• belongs to the cation transport ATPase (P-type) family, type IIC subfamily

Compartment

membrane

Expression

• predominant in neural & muscle tissues

Pathology

• defects in ATP1A2 are the cause of familial hemiplegic migraine 2
• defects in ATP1A2 are a cause of alternating hemiplegia of childhood

More general terms

• Na+/K+ ATPase-alpha
• transmembrane 10 protein
• phosphoprotein

Additional terms

• Na+/K+ ATPase

Database

• OMIM: https://mirror.omim.org/entry/104290
• OMIM: https://mirror.omim.org/entry/182340
• OMIM: https://mirror.omim.org/entry/602481
• UniProt: http://www.uniprot.org/uniprot/P50993.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=477