alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (alkylated DNA repair protein alkB homolog 2, oxy DC1, ALKBH2, ABH2)

Function

• dioxygenase
• repairs alkylated DNA & RNA containing 1-methyladenine & 3-methylcytosine by oxidative demethylation
• strong preference for double-stranded DNA
• low efficiency with single-stranded substrates
• requires molecular oxygen, alpha-ketoglutarate & iron
• activated by ascorbate

Cofactor: binds 1 Fe+2 per subunit

Structure

belongs to the alkB family

Compartment

• nucleus
• detected in replication foci during S-phase

Expression

• detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver & urinary bladder

More general terms

• dioxygenase
• metalloprotein
• nuclear protein
• alkylated DNA repair protein alkB homolog (ALKBH)

Database

• UniProt: http://www.uniprot.org/uniprot/Q6NS38.html