Xaa-Pro aminopeptidase 2; aminoacylproline aminopeptidase; membrane-bound aminopeptidase P; membrane-bound APP; membrane-bound AmP; mAmP; X-Pro aminopeptidase 2 (XPNPEP2)

Function

• metalloprotease
• may play a role in inflammatory processes & in response to injury or infection
• may also play a role in the metabolism of the vasodilator bradykinin
• release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide

Cofactor: binds 2 Mn+2 per subunit (putative)

Structure

• homotrimer
• heavily glycosylated
• belongs to the peptidase M24B family

Compartment

cell membrane; lipid-anchor, GPI-anchor

Expression

• expressed in kidney, lung, heart, placenta, liver, small intestine & colon
• not expressed in brain, skeletal muscle, pancreas, spleen, thymus, prostate, testis & ovary

More general terms

• glypiated protein
• Xaa-Pro aminopeptidase (XPNPEP)
• metalloprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7512
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7512
• OMIM: https://mirror.omim.org/entry/300145
• UniProt: http://www.uniprot.org/uniprot/O43895.html