NADP isocitrate dehydrogenase 2 (isocitrate dehydrogenase [NADP] mitochondrial)

Function

• catalyzes reversable conversion of isocitrate to 2-oxoglutarate
• role in intermediary metabolism & energy production
• may tightly associate or interact with pyruvate dehydrogenase complex

isocitrate + NADP+ <--> 2-oxoglutarate + CO2 + NADPH

Cofactor:

• binds 1 Mg+2 or Mn+2 per subunit

Structure

• homodimer
• belongs to the isocitrate & isopropylmalate dehydrogenases family

Compartment

mitochondria

Pharmacology

• IDH2 inhibitor enasidenib (Idhifa) FDA-approved for treatment of refactory acute myeloid leukemia (AML) with IDH2 gene mutation
• apparently IDH2 promotes cell growth of AML myelobasts
• vorasidenib (Servier) inhibits mutant IDH2 investigational treatment of gliomas with IDH2 gene mutation

Laboratory

• IDH2 gene mutation

More general terms

• NADP isocitrate dehydrogenase
• metalloprotein
• mitochondrial protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3418
• OMIM: https://mirror.omim.org/entry/147650
• UniProt: http://www.uniprot.org/uniprot/P48735.html