polyribonucleotide nucleotidyltransferase 1 (PNPase 1, polynucleotide phosphorylase-like protein, PNPase old-35, 3'-5' RNA exonuclease OLD35, PNPT1, PNPASE)

Function

• mRNA degradation
• hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
• homotrimer
• up-regulated in cells upon senescence & terminal differentiation
• up-regulated after treatment with interferon beta

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate

Structure

• contains 1 KH domain.
• contains 1 S1 motif domain Mitochondrion

More general terms

• nucleotidyltransferase
• mitochondrial protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TCS8.html