transcription termination factor, mitochondrial (mitochondrial transcription termination factor 1, mTERF)

Function

• transcription termination factor
• binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to & downstream of the 16S rRNA gene, this region comprises a tridecamer sequence critical for directing accurate termination
• probably requires one or more components for termination activity
• phosphoryation
  • DNA-binding activity is unaffected
  • only the phosphorylated form has termination activity

Structure

• monomer
• composed of 3 leucine zippers, one of which is bipartite, & 2 with widely spaced basic domains may form intramolecular three-stranded coiled-coil that brings the basic domains together to form a DNA-binding motif
• belongs to the mTERF family

Compartment

mitochondrion

More general terms

• mitochondrial protein

Database

• OMIM: https://mirror.omim.org/entry/602318
• UniProt: http://www.uniprot.org/uniprot/Q99551.html