C-Myc-binding protein; associate of Myc 1; AMY-1 (MYCBP, AMY1)

Function

• may control the transcriptional activity of MYC
• stimulates activation of E box-dependent transcription by MYC
• binds via its C-terminal region to the N-terminal region of MYC
• associates with AKAP1/S-AKAP84
• interacts with MYCBPAP

Structure

belongs to the AMY1 family

Compartment

• cytoplasm, nucleus, mitochondria
• translocates into the nucleus in S phase of the cell cycle upon an increase of MYC expression
• found in the mitochondria when associated with AKAP1

Expression

• highly expressed in heart, placenta, pancreas, skeletal muscle & kidney
• also expressed at low levels in lung

More general terms

• transcription factor, not classified
• nuclear protein
• mitochondrial protein

Additional terms

• c-myc proto-oncogene protein; transcription factor p64 (c-Myc, MYC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26292
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26292
• OMIM: https://mirror.omim.org/entry/606535
• UniProt: http://www.uniprot.org/uniprot/Q99417.html