protein tyrosine phosphatase mitochondrial 1; PTEN-like phosphatase; phosphoinositide lipid phosphatase (PTPMT1, MOSP, PNAS-129)

Function

• dephosphorylation of mitochondrial proteins, thus role in ATP production.
• preference for phospho Ser &/or phospho Thr, rather than phospho Tyr
• regulation of insulin secretion in pancreatic beta cells

Structure

• belongs to the protein-tyrosine phosphatase family non-receptor class dual specificity subfamily
• contains 1 tyrosine-protein phosphatase domain

Compartment

• mitochondrial
• associated with mitochondrial inner membrane

Alternative splicing

named isoforms=2

More general terms

• serine/threonine phosphatase
• tyrosine phosphatase (protein tyrosine phosphatate, PTP)
• mitochondrial protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=114971
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:114971
• OMIM: https://mirror.omim.org/entry/609538
• UniProt: http://www.uniprot.org/uniprot/Q8WUK0.html