5'(3')-deoxyribonucleotidase, mitochondrial; 5',3'-nucleotidase, mitochondrial; deoxy-5'-nucleotidase 2; dNT-2 (NT5M, DNT2)

Function

• dephosphorylates 5' & 2'3'-phosphates of deoxyribonucleotides
• preference for dUMP & dTMP
• regulates dTMP levels in mitochondria
• protects mitochondrial DNA replication from excess dTTP
• marginal activity towards dIMP & dGMP

Cofactor: Mg+2

Structure

• homodimer (probable)
• belongs to the 5'(3')-deoxyribonucleotidase family

Compartment

mitochondria

Expression

• highly expressed in heart, brain & skeletal muscle
• detected at very low levels in kidney & pancreas

More general terms

• exodeoxyribonuclease
• mitochondrial protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56953
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56953
• OMIM: https://mirror.omim.org/entry/605292
• UniProt: http://www.uniprot.org/uniprot/Q9NPB1.html