5'(3')-deoxyribonucleotidase, cytosolic type; cytosolic 5',3'-pyrimidine nucleotidase; deoxy-5'-nucleotidase 1; dNT-1 (NT5C DNT1 UMPH2)

Function

• dephosphorylates the 5' & 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP & dTMP,
• intermediate activity towards dGMP, & low activity towards dCMP & dAMP

Cofactor: Mg+2

Structure

• homodimer
• belongs to the 5'(3')-deoxyribonucleotidase family

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• detected in skeletal muscle, heart & pancreas

More general terms

• exodeoxyribonuclease

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=30833
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:30833
• OMIM: https://mirror.omim.org/entry/191720
• UniProt: http://www.uniprot.org/uniprot/Q8TCD5.html