CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial; phosphatidylglycerophosphate synthase 1; phosphatidylglycerophosphate synthase; PGP synthase (PGS1)

Function

• functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol & cardiolipin
• activated by Ca+2 & Mg+2
• inhibited by other bivalent cations (putative)
• phospholipid metabolism; phosphatidylglycerol biosynthesis
• phosphatidylglycerol from CDP-diacylglycerol: step 1/2

CDP-diacylglycerol + sn-glycerol 3-phosphate
                 <-->
CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate

Structure

• belongs to the CDP-alcohol phosphatidyltransferase class-II family
• contains 2 PLD phosphodiesterase domains

Compartment

mitochondria (putative)

Alternative splicing

named isoforms=4

More general terms

• phosphotransferase
• mitochondrial protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9489
• UniProt: http://www.uniprot.org/uniprot/Q32NB8.html