thymidine kinase 2, mitochondrial; Mt-TK (TK2)

Function

• deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, & deoxyuridine
• also phosphorylates antiviral & anti-neoplastic nucleoside analogs

ATP + thymidine = ADP + thymidine 5'-phosphate

Structure

• monomer
• belongs to the DCK/DGK family

Compartment

mitochondria

Alternative splicing

named isoforms=2; long, short

Expression

• predominantly expressed in liver, pancreas, muscle, & brain

Pathology

• defects in TK2 are a cause of myopathic mitochondrial DNA depletion syndrome

Laboratory

• MT-TK gene mutation

More general terms

• thymidine kinase
• mitochondrial protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7084
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7084
• OMIM: https://mirror.omim.org/entry/188250
• OMIM: https://mirror.omim.org/entry/609560
• UniProt: http://www.uniprot.org/uniprot/O00142.html