carbonic anhydrase-5B (carbonic anhydrase VB, mitochondrial carbonic anhydrase)

Function

• reversible hydration of CO2

H2CO3 <--> CO2 + H2O

Cofactor: Zn+2 (putative)

Structure

belongs to the alpha-carbonic anhydrase family

Compartment

mitochondria

Expression

• strongest expression in heart, pancreas, kidney, placenta, lung, & skeletal muscle
• not expressed in liver

Notes

• inhibition of mitochondrial carbonic anhydrase suggested to have benefit for aging & neurodegenerative disease

More general terms

• carbonic anhydrase (dehydratase)
• mitochondrial protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1123
• OMIM: https://mirror.omim.org/entry/300230
• UniProt: http://www.uniprot.org/uniprot/Q9Y2D0.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11238